Antihypertensive Efficacy of Aliskiren

Antihypertensive efficacy of aliskiren: is hydrochlorothiazide an appropriate benchmark?

The thorough prospective, randomized, double-blind trial of Schmieder et al1 in the current issue of Circulation convincingly documents that aliskiren treatment provided significantly greater blood pressure (BP) reduction than hydrochlorothiazide. The study is well done; the number of patients (n 1124) is impressive; and the efficacy variables were analyzed, as is appropriate for an intention-t...

Aliskiren, a novel orally effective renin inhibitor, provides dose-dependent antihypertensive efficacy and placebo-like tolerability in hypertensive patients.

BACKGROUND Stopping the detrimental effects of the renin-angiotensin system at the most upstream point of the cascade offers theoretical advantages for cardiovascular protection. This study compares the antihypertensive efficacy and safety of the novel oral renin inhibitor aliskiren with placebo and an active comparator. METHODS AND RESULTS The study was a randomized, multicenter, double-blin...

Renal protective effects of aliskiren beyond its antihypertensive property in a mouse model of progressive fibrosis.

BACKGROUND The direct renin inhibitor aliskiren is known to exhibit a strong antihypertensive effect. However, the organoprotective potential of aliskiren beyond its antihypertensive properties is less clear. This study investigates the antifibrotic nephroprotective effects of aliskiren in a nonhypertensive mouse model for progressive renal fibrosis. METHODS COL4A3(-/-) mice received aliskire...

Assessing Clinical Efficacy of Available Antihypertensive Agents

A retrospective clinical study of the safety and efficacy of AFA mixture, an herbal antihypertensive product

Background & Aim: Hypertension is an incurable disease which has become a common major risk factor for many cardiovascular diseases worldwide. Besides increasing the risk of heart diseases and stroke, hypertension can also lead to other health conditions such as renal disease and diabetes. The prolong use of orthodox antihypertensive are usually associated with many side effect...